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Probiotics And Immunity
- Sep 27, 2018 -

The gut is a solid wall of immunity. The thin mucous membrane is the first physical barrier, keeping a distance from all kinds of bad bacteria and toxins in the intestinal cavity, protecting our intestinal tract. Then there are the well-organized immune cells lining the wall of the gut, and probiotics can stimulate our immune cells, activate them, and then work their way through the body. The gut is our main training base for immunity, and probiotics are our trainers. Probiotics can be said to be immune messengers.

There are two types of immunity: cellular immunity and humoral immunity.

In cellular immunity, probiotics can activate macrophages, which can engulf and kill a variety of pathogenic microorganisms while inducing the release of two weapons - tumor necrosis factor (TNF- type) and interleukin 6 (il-6). Tumor necrosis factor, as the name implies, is to the cancer cell has the killing effect, causes the tumor hemorrhage necrosis active factor. Interleukin is also an important immune active factor, which is involved in the inflammatory response and regulates the immune function of the body. Both the extracellular products of probiotics and the peptidoglycan of cell wall have certain immunological activities. Intact cells (or intact peptides) may play an immune adjuvant activity. But studies have shown that even bifidobacterium genomic DNA can activate macrophages in bacterial cell breakage. This is why ordinary, non-living yogurt also has a certain immune function.

Probiotics can also activate T cells and NK cells (Natural Killer cells), both of which can play a cell-killing role and block invading cells.

Other studies have shown that certain probiotics promote the proliferation of spleen cells, increase the weight of the spleen, and enhance immune function. And can produce other cytokines such as interleukin -1, interleukin -10 (il-1, il-10) or interferon.

In humoral immunity, another type of immune cell B cells are stimulated by probiotics and the production of different types of antibody immunoglobulin (IgA) increases. Then, it binds to a secretory cell protecting immune globulin to become sIgA, which is then released by intestinal mucosa epithelial cells, inhibits the colonization of pathogenic microorganisms and enhances the immune response 


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