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Relationship Between Probiotics Membrane And Pathogenic Bacteria Membrane
- Jul 18, 2018 -

Human flora is composed of resident flora and passageway flora. As long as the resident flora remains normal, the passageway flora is generally not important. However, if the resident flora is abnormal, the potential pathogenic microorganisms of the bacteria can proliferate and cause diseases, usually exogenous infections.

Human settlement flora consists of beneficial bacteria, pathogenic bacteria and conditional pathogenic bacteria, the proportion of 20:10:7 0, when the bacteria when the proportion of more than 20, good effect will happen conditional pathogenic bacteria into beneficial bacteria to human body. However, if the proportion of pathogenic bacteria increases, opportunistic pathogens will cause diseases, usually endogenous infections. Therefore, in addition to beneficial bacteria, the composition of beneficial bacteria film is mostly opportunistic pathogens and a small number of pathogenic bacteria. However, when the number of beneficial bacteria increases, the structure of beneficial bacteria film becomes more stable.

Competing with pathogenic bacteria membrane adhesion

Because there are some pathogenic bacteria in the composition of the beneficial bacteria membrane, the beneficial bacteria and pathogens compete all the time, including nutrition competition and occupation competition. Once the pathogen gets the advantage and completes the initial adhesion to the surface substrate, the pathogen film will be formed when the opportunistic pathogen keeps adhesion. At the same time, if the beneficial bacteria in the body lose their dominant position and cannot complete the basic conditions for the formation of the beneficial bacteria membrane, the possibility of the pathogenic bacteria in the passing bacteria to form the pathogenic bacteria membrane is also greatly increased.

In most human bacterial infection diseases, pathogenic bacteria form bacterial membranes to resist host immune system and drug treatment, which is one of the important reasons for antibiotic resistance. Bacterial membrane pathogens are often hundreds to thousands of times more resistant to antibiotics than plankton pathogens. Staphylococcus aureus, for example, is a conditional pathogen, with a fatality rate of up to 90% after infection. Research shows that staphylococcus aureus has strong resistance to antibiotics of the reason is that it has a strong ability of biofilm formation, the antimicrobial hard infiltration within the biofilm effective antiseptic effect.

As it is difficult for antibiotics to permeate the pathogenic bacteria membrane, the combination of antibiotics that can permeate the bacteria membrane and inhibit the formation of the bacteria membrane are generally used in the treatment. Such as fluoxacin, gatifloxacin and other quinolones and clarithromycin, azithromycin, roxithromycin and other macrolides. The antibiotics are broad spectrum antibiotics, have broad bactericidal effect, the treatment of a certain parts of the body when bacteria biofilm infections, other parts to the whole body of beneficial bacteria in the film the same damage, seriously destroy the mucosal immune, more vulnerable to the threat of bacterial infection in life in the future.

Inhibit the formation of pathogenic bacteria membrane

Beneficial bacteria in the stability of the membrane structure and balanced nutrition, physiological and immune function of host, aging, cancer and so on have great influence, their potential conditional pathogenic bacteria or protection against foreign pathogens, which prevent these bacteria to colonize effect on mucosal, also known as flora barriers (barrier effect), it is one of the important mechanism of the micro ecological balance control flora, also make humans from foreign bacterial infection of a reliable guarantee.

Such as bifidobacterium lactobacillus or through teichoic acid interact with intestinal mucosa epithelium, close union, together with other anaerobe and orderly engraftment in gastrointestinal mucous membrane surface, the formation of beneficial bacteria in the gastrointestinal tract, membrane potential pathogenic bacteria in the gastrointestinal tract and exogenous in intestinal epithelial cell adhesion, engraftment, engraftment resistance effect; Gastrointestinal inside the beneficial bacteria such as lactobacillus, on the other hand also has a variety of biological antagonism function, such as by competition for nutrition and reduce the gastrointestinal PH, produce acidic metabolites have spectrum antibacterial effect of material such as fat molecules, the chemical material such as hydrogen peroxide, within the gastrointestinal on e. coli, streptococcus, such as bacteriostatic and bactericidal effect, inhibit the growth of intestinal exogenous pathogenic bacteria.

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